'Miracle cure' saves breast cancer patient with only months to live

07 Junio, 2018, 01:03 | Author: Earnest Bishop
  • The study is thought to be the largest breast cancer treatment trial ever

"Where you can say, 'Well, we didn't know this before, now we do". "Which is delivering the most effective and least toxic therapy to patients".

Arnie Purushotham, a senior clinical adviser to Cancer Research UK who was not involved in the study, welcomed the TAILORx results as an important step toward making cancer treatment less harsh for patients. "While this practice has contributed to declining rates in breast cancer mortality, "...the majority of patients may receive chemotherapy unnecessarily". Dr Alistair Ring, consultant medical oncologist at the Royal Marsden NHS Hospital in London, said: "I think this is a fundamental change in the way we treat women with early-stage breast cancer and will lead to a considerable number of women no longer needing to have chemotherapy".

The latest results should mean more women can avoid chemotherapy, and its associated side effects, without compromising the effectiveness of their treatment.

Researchers at the National Cancer Institute have put a patient with metastatic breast cancer into complete remission by using a new approach to immunotherapy.

"For the entire study population with gene test scores between 11 and 25 - and especially among women aged 50 to 75 - there was no significant difference between the chemotherapy and no chemotherapy groups", said the findings, published in the New England Journal of Medicine. "It felt like the worst flu I'd ever had times ten, and you have absolutely no energy". "Now I'm going to say, 'Hey, you don't need it. Look at these numbers; you're going to be fine'".

Cancer doctors said the findings would change practice in United Kingdom clinics, and meant women in this group could be treated safely with just surgery and hormone therapy.

But Drs Sparano and Mayer added a note of caution: The data indicated that some women 50 and younger might benefit from chemo even if gene-test results suggested otherwise.

Jennifer Mall, 47, of Downers Grove, Ill., was a patient of Albain's who agreed to participate in the study.

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According to the American Cancer Society, one in eight women will develop breast cancer in her life.

Harold Burstein, a breast cancer specialist at Dana-Farber Cancer Institute, said that in some ways the debate over de-escalation misses a larger issue.

Judy Perkins had hormone receptor-positive breast cancer that had spread to her liver and other organs and had exhausted all other treatment options, including several rounds of chemotherapy, and none had stopped the disease progressing.

Using a technique called adoptive cell transfer, scientists removed a tumour from her chest and determined which friendly T cells within it were capable of recognising the harmful cancer cells.

It's a word that strikes fear into most, but with one in two people are diagnosed with cancer in their lifetime. "This is very good", said Sarin.

Researchers share preliminary and more advanced results. At least 30-40 per cent patients, to whom we advice Oncotype DX, come in this score range. The study also has the potential to improve access to health care by keeping costs down for women who do not need chemotherapy, Olopade said.

He pointed out that by having this trial in Ireland, this has allowed more personalised treatment recommendations for women with this type and stage of breast cancer.

In an attempt to settle this question, investigators designed a clinical trial that assessed the long-term outcomes in women receiving radiation to their IM-MS lymph nodes compared to a control group that did not.

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