Ibuprofen Was Just Linked to Male Infertility

10 Enero, 2018, 00:54 | Author: Earnest Bishop
  • The study found that taking ibuprofen for extended periods could have an impact on male fertility

Before you go raid your medicine cabinet, Advil and Motrin are two brand names for ibuprofen. And now, new research shows that it can cause infertility, erectile dysfunction, muscle atrophy and fatigue in men.

According to the Proceedings of the National Academy of Sciences, prolonged and heavy use of the drug "alters human testicular physiology to produce a state of compensated hypogonadism".

Epidemiological studies have shown that NSAID exposure was associated with reduced testosterone and congenital malformations; another study showed a drop in a testosterone metabolite among men who were taking ibuprofen regularly.

David M. Kristensen, study co-author and a senior scientist in the Department of Neurology at Copenhagen University Hospital, says taking these drugs during pregnancy even "increased the likelihood that male babies would be born with congenital malformations".

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The study, which took place in Denmark and France, included 31 adult men under the age of 35.

The Consumer Healthcare Products Association, a trade group that represents manufacturers of over-the-counter medications and supplements, "supports and encourages continued research and promotes ongoing consumer education to help ensure safe use of OTC medicines", Mike Tringale, a spokesman for the association, told CNN. The remaining participants were given a placebo. After 14 days of ibuprofen use, the researchers observed higher blood levels of luteinizing hormone, which regulates the production of testosterone and other hormones. Testosterone production, however, did not increase concurrently, resulting in a lower ratio of testosterone to luteinizing hormone - a sign of hypogonadism, according to the paper.

The finding comes after repeated warnings from other researchers that ibuprofen can raise the risk of heart attacks in the general population and cause medical problems for pregnant women and their babies, including a more than doubling of the risk of miscarriage. Jégou said that for the small group who used the drug for a short time, the effects appeared to be reversible. However, with the discovery comes the concern that long-term usage of high doses of ibuprofen might make compensated hypogonadism a permanent condition.

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