How drinking alcohol 'snaps' DNA, raising your cancer risk

06 Enero, 2018, 01:16 | Author: Enrique Watson
  • How drinking alcohol 'snaps' DNA, raising your cancer risk

Alcohol damages the DNA of stem cells responsible for producing new blood, according to a mouse study which may explain the link between drinking and cancer, scientists said on Wednesday.

Although alcohol isn't thought to cause blood cancers, blood stem cells offer a valuable way for scientists to investigate what's happening to the DNA inside. The researchers found that acetaldehyde snaps the DNA of stem cells, permanently altering the genetic code and triggering cancer.

Health watchdogs have long warned that alcohol consumption contributes to seven types of cancer - of the mouth, throat, larynx or voice box, oesophagus or food pipe, breast, liver and bowel.

She said: 'This is handsome work which puts our finger on the molecular basis for the link between alcohol and increased cancer risk and stem cells'.

Now researchers have found for the first time "a simple plausible explanation" of why alcohol can causes our cells to go haywire - by causing damage to our DNA.

Much previous research looking at the precise ways in which alcohol causes cancer has been done in cell cultures. But millions of people all over the world, especially in South East Asia, do not have these protective enzymes in their bodies, with the effect that alcohol consumption hides more risks for them. Unrepaired breaks can lead to large deletions and chromosome rearrangements, and the mutations are passed on to daughter cells that make up the blood.

Professor Ketan Patel, lead author of the study and scientist, part-funded by Cancer Research UK, at the MRC Laboratory of Molecular Biology, said: "Some cancers develop due to DNA damage in stem cells".

Normally, the enzyme aldehyde dehydrogenase 2 (ALDH2) quickly oxidizes acetaldehyde into acetate, which cells use as a source of energy.

More news: Spurs reportedly tried 'really, really hard' to get Kyrie Irving in trade
More news: Envían mensajes de apoyo a Jürgen Damm, tras quemarse con cohetes
More news: USA seeks United Nations emergency meeting on Iran on Friday

The study said that over 540 million people in Asia carry a mutation in the ALDH2 gene, which means they can't process acetaldehyde which causes the widely documented red flush reaction in Asians.

"But it's important to remember that alcohol clearance and DNA fix systems are not flawless and alcohol can still cause cancer in different ways, even in people whose defence mechanisms are intact". As a result, while they drink, acetaldehyde builds up, causing a flushed complexion along with as a feeling of discomfort.

They found that ALDH2-deficient mice had four times the cell damage as control mice with normal ALDH2 production.

The second line of defence involves a variety of DNA repair systems that allows cells to fix numerous different types of damage.

Professor Patel said: 'Our study highlights that not being able to process alcohol effectively can lead to an even higher risk of alcohol-related DNA damage and therefore certain cancers.

It has been estimated nearly six per cent of all cancer deaths worldwide could be attributed to alcohol.

"We know that alcohol contributes to over 12,000 cancer cases in the United Kingdom each year, so it's a good idea to think about cutting down on the amount you drink", she said.

Recomendado:



Popular

David Silva says prematurely born son is 'fighting day by day'
David Silva has revealed the premature birth of his son Mateo is behind his recent absence from the Manchester City squad. City will no doubt miss Silva in each match that he's absent but everyone is wishing him and his family all the best.

FedEx employee from Tennessee discovers largest known prime number
Prime numbers are divisible only by themselves and one, and the search for ever-larger primes has long occupied maths enthusiasts. You do not expect to find yourself so close to each other, "said Tennessee University professor of mathematics, Chris Caldwell".

Justin Bieber museum exhibit to open in his hometown
Global music sensation. "That sort of stuck with me". "I started to think about Justin Bieber and people like that", Kastner said. Even if not everyone is ready to catch Bieber fever, he hopes they'll understand why the museum thinks this exhibit makes sense.

Ecuador conforma su lista definitiva para el Sudamericano Femenino Sub 20
Los dos primeros de cada grupo accederán al cuadrangular final que da la clasificación a dos selecciones para la cita planetaria. Será un duro campeonato debido a que sólo entrega dos plazas para el Mundial de Francia de este año.

Intendencia del Guayas investiga "arroz plástico"
Después se desmintió esta información y en el lugar realmente se realizan procesos de reciclaje. Ella lo demuestra quemando el producto en una hornilla.

Marathon Petroleum Corporation (MPC), Ecopetrol SA (EC)
Cibc Asset Mngmt reported 0% of its portfolio in Murphy Oil Corporation (NYSE: MUR ). 629,053 are owned by Voya Inv Mgmt Limited. The British Columbia - Canada-based British Columbia Management has invested 0.18% in Marathon Petroleum Corporation (NYSE:MPC).

Cinismo o amnesia en materia de seguridad: Nuño a AMLO
El exsecretario de Educación Pública reiteró que López Obrador hizo alianza con Elba Esther Gordillo, porque obviamente los niños y las niñas lo tienen sin cuidado.

Year of the Moon
This year , however, will see two occurrences of two full moons in a month, with the second blue moon occurring on 31 March. Those on MST, CST, and EST will be able to see the same at 4:48 a.m., 5:48 a.m., and 6:48 a.m. respectively.

Jeopardy! Pauses Production While Host Alex Trebek Recovers from Brain Surgery
Trebek, who is from a nickel-mining town in Ontario, Canada, suffered a heart attack in 2012 and was hospitalised for another in 2007.

More than 100 Sears and Kmart stores to close in spring
Closeout sales at the affected locations will begin next week with all 103 locations shuttered by May. Liquidation sales will start as early as January 12 at the stores closing.